Falling prices for digital assets such as bitcoin hurt start-ups

Diurnal, Tissue Regenix and Beximco went through long process of bringing products to market

Small-caps aim to carve out a slice of booming industry

Tighter regulations in home market contrast sharply with loosening in US

UK specialists add substance to government’s ‘Global Britain’ slogan

Smaller E&P players and majors jostle for acreage in African frontier region

Worldwide sales of orphan drugs are forecast to total $262bn by 2026

London-listed groups have struggled to regain growth at home

Beer sales fell 1.7% in first quarter but sector expected to get boost from World Cup

Flurry of M&A activity suggests optimism in a sector with significant overseas exposure

Focus of investors is on companies with reserves, production and cash flow

There were 275 more shop closures than openings in the region in the first quarter

$2.6bn cost for taking a medicine from discovery to market remains stubbornly high

Avon Rubber, Trifast and Xaar manufacture niche and high-value products

Infrastructure funds have long been backers of renewable energy projects

Small UK companies look to take advantage of popular and unconventional field

Some publishers have struggled to replicate the success of early hits

Achieving commercial breakthroughs for an innovation that is still very costly has proved hard