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Analysts believe M&A will continue as companies continue to automate jobs
Focus of investors is on companies with reserves, production and cash flow
There were 275 more shop closures than openings in the region in the first quarter
$2.6bn cost for taking a medicine from discovery to market remains stubbornly high
Avon Rubber, Trifast and Xaar manufacture niche and high-value products
Infrastructure funds have long been backers of renewable energy projects
Small UK companies look to take advantage of popular and unconventional field
Some publishers have struggled to replicate the success of early hits
Achieving commercial breakthroughs for an innovation that is still very costly has proved hard
