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David Cameron faced a growing backlash to his draft EU deal, as his fight begins to keep Britain in Europe. The outline of a long-awaited reform deal gave him the power to restrict benefits for new migrant workers for up to four years.

But some UK media outlets lambasted his proposals as falling short of expectations, while one Conservative sceptic said up to five cabinet ministers would back Brexit. (FT, Guardian)

In the news

China’s record takeover China National Chemical Corp has agreed to buy Syngenta for $43bn, in the most ambitious foreign takeover yet by a Chinese company. (FT)

First US Zika case probably sexually transmitted Officials in Texas, where the first known case of the disease’s transmission in the US was reported on Tuesday, said it was probably spread through sexual contact rather than a mosquito bite. Meanwhile, France’s Sanofi became the first drugmaker to announce a research and development plan to target the disease, saying its existing infrastructure could be “rapidly leveraged” to speed identification of a vaccine candidate. (Reuters, FT)

Cruz and Clinton notch up victories Texas Senator Ted Cruz treated Donald Trump to a humbling defeat, while Hillary Clinton secured the slimmest of victories over Democratic rival Bernie Sanders in the first 2016 nominating contests It sets up bitter fights on both sides as the campaign heads to New Hampshire, but isn’t likely to end the GOP’s Trump nightmare. The “virtual tie” may be better for Clinton than Sanders, in a state tailored to his strengths. (FT, NYT, TNR)

Yahoo cuts jobs, explores spin-off The tech company will lay off 15 per cent of its workforce and is exploring strategic alternatives, which could include a sale of its core internet business, in an effort to appease activist investors. (FT)

New York’s Chinese boom Corporations have joined wealthy individuals in betting on the US property market. Buyers spent $28.6bn in the 12 months to last March. (NAR)

It’s a big day for

Ireland Enda Kenney, the prime minister, has triggered elections later this month, five years after his centre-right Fine Gael party won its biggest ever share of the vote. (FT)

Food for thought

Guinea worm turned Jimmy Carter, the former US president, believes the disease may soon be eliminated — progress he would consider the most exciting accomplishment of his career. (AP/ABCNews)

Connectivity is not enough Linking everyone to the internet won’t solve the world’s development problems. Four-fifths of people in poorer countries own a mobile phone but the digital dividend is unevenly spread. (The Conversation)

Luxembourg’s asteroid mining plan It may be the cause of a commodity price bear market in decades to come, but the small European country is preparing to launch an official initiative to promote the mining of asteroids for metals and other materials that are scarce on Earth. (FT)

Pacific trade pact’s big ambition could be its undoing The trade ministers of 12 Pacific Rim nations meet in New Zealand this week to sign the Trans-Pacific Partnership agreement. Then they need domestic ratification. For some, the negotiations will be especially challenging, writes Edward Alden of the think-tank Council on Foreign Relations in Washington. (NAR)

Video of the day

ChemChina-Syngenta deal The $43bn deal between ChemChina and Syngenta explained in 60 seconds. (FT)


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