A profit warning sent Plus500 plunging, with the contracts-for-difference bookmaker also revealing for the first time how much its earnings relied on betting against its customers.

The company posted a $56m trading gain from client losses during a volatile fourth quarter, the equivalent to about a third of total group revenue.

Tui hit its lowest in nearly three years after first-quarter results disappointed, in spite of a profit warning last week.

The travel group reported a wider than expected underlying loss of €83.6m on weak numbers from its markets and airlines division, which suffered from disappointing demand from northern territories, including the Nordics.

Burberry edged higher in response to reassuring results from Gucci owner Kering, which said that Chinese luxury goods demand remained strong.

Hospital operator Spire Healthcare faded after Credit Suisse advised selling.

It predicted a tougher 2019 for UK private hospitals and argued that soft volumes from the NHS had reduced Spire’s profitability and eroded the value of its property portfolio.

Britvic weakened after Morgan Stanley downgraded the drinks maker to “equal weight”.

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