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For decades dementia has been feared and little understood. But new hope is being raised of a cure

Chancellor outlines plans after biggest cuts to growth forecasts since financial crisis

US president’s company to walk away from signature Manhattan building

Lobby group urges government to incorporate a host of international agreements into UK law

Car-booking company concealed attack that compromised information of 57m people

Emma Jacobs takes a crash course in the elusive quality everyone wants

Dublin, rattled by prospect of damaging its €65bn annual trade with its biggest market, could derail negotiations

Spending at 20-year low threatens region’s prosperity, EIB report warns

Former vice-president to be sworn in on Friday to assume top job following Mugabe’s resignation

Foreign policy blueprint urges focus on US to balance growing Chinese power in region

French cable group struggling to reassure investors after share price halves

Exchange accused of allowing Chinese group to trade untraceable metal in London

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US News

Investors have made a decisive bet that some traditional stores will not survive

Broadband and media markets remain resilient even as FCC moves to scrap 2015 regulations

Outgoing Fed chair reaffirms uncertainty over whether bank clearly understands causes

Proportion of fixed-rate loans is highest on record, prompting caution at regulator

Opinion

The politics of plenty once led politicians to lift their sights to Europe. No longer

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What the chancellor's measures mean for the economy and your finances

Highlights

Big groups snap up much talent, only to then stifle originality

Apple supplier Foxconn among those turning to students as flexible workers dwindle

Tech chiefs are finding a wealth of expertise in neglected middle America

Markets News

Pace of rate rises in 2018 in doubt as US central bank struggles with low inflation

updated

Investors have made a decisive bet that some traditional stores will not survive

Many policymakers conclude increase needed if economy stays on track

Technology

Tech chiefs are finding a wealth of expertise in neglected middle America

Game champ Oriol Vinyals shows machines how to play popular 1990s shoot-’em-up

Life & Arts